Alteration in prehospital drug concentration after thermal exposure.
The American journal of emergency medicine · 2008-06-01 · Method & validation
Abstract
OBJECTIVE: The aim of the study was to determine the remaining concentration of 23 commonly carried emergency medical services medications used in the United States after they have experienced thermal extremes that have been documented in the prehospital environment for a period of 1 month. METHODS: Pharmaceuticals were thermally cycled (-6 degrees C and 54 degrees C) every 12 hours and then assayed by high-performance liquid chromatography. RESULTS: Eight (35%) of 23 prehospital pharmaceuticals revealed ending concentrations of less than 90% with strong correlation to thermal exposure time. These included lidocaine, diltiazem, dopamine, nitroglycerin, ipratropium, succinylcholine, haloperidol, and naloxone. CONCLUSION: A decrease in concentration was found to be statistically significant in 8 (35%) of 23 commonly carried emergency medical services pharmaceuticals. These results provide new information and perspective regarding stability of emergency drugs in the prehospital environment by evaluating a broad range of pharmaceuticals as well as by using thermal exposure points that have been documented in the United States.
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Tags
Cardiovascular drugs · Respiratory drugs · Glyceryl trinitrate · Anaesthetics · Sedatives & anxiolytics · Muscle relaxants · Lidocaine · Antidotes · Suxamethonium · Antipsychotics · Ipratropium · Naloxone
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