Pre-hospital thrombolysis in perspective.
European Heart Journal · 2008-10-23 · Other / unclear
Abstract
AIMS: To review existing evidence on the role of pre-hospital fibrinolysis in patients with ST-elevation myocardial infarction (MI). METHODS AND RESULTS: Overview of current guidelines and data from trials and registries on the best perfusion approach for acute MI with ST-elevation. Despite advances in the treatment of ST-elevation MI, the mortality rate before any therapy is administered is high, with half of all fatalities occurring within 2 h of symptom onset. Current treatment options, including the timely use of pre-hospital fibrinolysis, have reduced the overall 1 month mortality. Mortality can be further improved when patient characteristics, risk factors and time delays to treatment are considered. CONCLUSION: Time factors are essential in the success of fibrinolysis, and subsequent coronary intervention seems beneficial.
Tags
Antithrombotics & thrombolytics · Thrombolytics · Time intervals