[The diagnostic significance of the content in blood plasma of troponin and protein of cardiomyocytes binding fatty acids under acute coronary syndrome].
Klinicheskaia laboratornaia diagnostika · 2016-10-01 · Other / unclear
Abstract
The content of fatty acids-binding protein in blood serum increases in 2-3 hours after acute coronary syndrome and myocardium infarction and reaches its maximal value after 8/5 hours in average after beginning of cardiomyocytes destruction. To the end of the first day of acute coronary syndrome the content of fatty acids-binding protein in blood significantly decreases due to excretion with urine. The level of fatty acids-binding protein in blood during a day remains slightly higher than initial one. The high clinical sensitivity and relatively high organ specificity is characteristic for fatty acids-binding protein in 12 hours after acute coronary syndrome. In early terms of myocardium infarction clinical specificity of fatty acids-binding protein is prevailed over concentration of troponins. In 12 hours after acute coronary syndrome troponins begin to manifest higher clinical and sensitivity and diagnostic specificity that dominate during several days of myocardium infarction. Under simultaneous measurement of fatty acids-binding protein and troponins sensitivity and of biochemical diagnostic increases up to 30% during first 12 hours. In later time periods advantage of simultaneous detection of fatty acids-binding protein and troponins stops to be necessary. At this time, fatty acids-binding proteins are evacuated through kidneys with urine excretion. After 12 hours the diagnostic significance of detection of troponins becomes dominating. No relationship between was established between content and of fatty acids-binding proteins in blood serum and indications of reperfusion of myocardium according electrocardiogram data. The possible cause is probably related to rare blood sampling for detection of fatty acids-binding protein such a dynamic test. The test doesn't do for evaluating the condition of patients with circulatory deficiency because of results not enough adequate. The best alternative of differentiate diagnostic during first day of acute coronary syndrome would be application of combined express immune chromatographic test permitting “at bedside of patient" or in ambulance car to dynamically and simultaneously detect fatty acids-binding proteins and troponins in whole blood and “to preserve" the results up to objective assessment.