Lower versus higher oxygen targets after resuscitation from out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized controlled trials.
Journal of Critical Care · 2023-10-18 · Meta-analysis
Abstract
PURPOSE: To update the existing evidence and gain further insight into effects of lower versus higher oxygen targets on the outcomes in patients resuscitated from out-of-hospital cardiac arrest (OHCA). METHODS: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing lower versus higher oxygen targets on the outcomes among adults resuscitated from OHCA. The primary outcome was short-term survival (in hospital or within 30 days). Subgroup analyses were performed according to timing of study interventions. RESULTS: Seven RCTs with 1454 patients were finally included. The short-term survival did not differ between the two groups with a relative risk (RR) of 0.98 (95% CI, 0.86 to 1.11). There were no significant differences in survival at longest follow-up (RR, 1.01; 95% CI, 0.91 to 1.14), favorable neurological outcome (RR, 1.00; 95% CI, 0.91 to 1.11), length of intensive care unit stay (mean difference, -4.94 h; 95% CI, -14.83 to 4.96 h), or risk of re-arrest (RR, 0.68; 95% CI, 0.21 to 2.19). The quality of evidence ranged from moderate to very low. CONCLUSION: Current evidence suggests that targeting a lower or higher oxygen therapy in patients after resuscitation from OHCA results in similar short-term survival and other clinical outcomes.
Abstract © the authors or publisher, via PubMed. Reuse and removal
Tags
Other drugs · Mortality & survival · Quality of life & function · Oxygen
Related articles
- Conservative Versus Higher Oxygen Targets Post-Cardiac Arrest: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis. (Acad Emerg Med, 2026)
- Oxygen and carbon dioxide targets after cardiac arrest: an updated systematic review. (Resuscitation, 2025)
- Canadian Cardiovascular Society/Canadian Cardiovascular Critical Care Society/Canadian Association of Interventional Cardiology Clinical Practice Update on Optimal Post Cardiac Arrest and Refractory Cardiac Arrest Patient Care. (Can J Cardiol, 2024)
- Oxygen Targets After Cardiac Arrest: A Meta-analysis of Randomized Controlled Trials. (Am J Ther, 2023)
- Oxygen targets following cardiac arrest: A meta-analysis of randomized controlled trials. (Int J Cardiol Heart Vasc, 2023)
- Oxygenation and ventilation targets after cardiac arrest: A systematic review and meta-analysis. (Resuscitation, 2020)