Impact of resuscitation duration on 12-month functional recovery following out-of-hospital cardiac arrest with initially shockable rhythms.
Resuscitation · 2025-09-12 · Observational study
Abstract
AIM: To describe the impact of cardiopulmonary resuscitation (CPR) duration on the 12-month functional recovery and health-related quality of life (HRQoL) outcomes of out-of-hospital cardiac arrest (OHCA) patients with initially shockable rhythms. METHODS: We performed a retrospective analysis of adults (aged ≥18 years) who had an emergency medical service (EMS) attempted resuscitation with an initially shockable rhythm between 2015 and 2024. We excluded paediatric cases, traumatic aetiology and EMS witnessed OHCA. Survivors to hospital discharge were followed up 12 months post-arrest to assess functional recovery according to the Glasgow Outcome Scale-Extended. CPR duration was defined as the total cumulative EMS resuscitation time until either return of spontaneous circulation or resuscitation termination. RESULTS: Of the 7922 OHCA with an initially shockable rhythm, 6371 met the inclusion criteria. 2054 (32.6 %) patients survived to hospital discharge. Of those, 1769 (86.1 %) patients were confirmed alive at 12-months, and 1429 responded to follow-up. The 50th, 90th, and 99th percentiles of CPR duration for those who survived to 12 months with favourable functional recovery were 8, 25, and 69 min, respectively. Among all patients with initially shockable rhythms, each minute increase in CPR duration was associated with reduced risk-adjusted odds of 12-month favourable functional recovery (AOR = 0.905, 95 %CI 0.899-0.911) and HRQoL. Among 12-month responders only, increasing CPR duration was associated with lower odds of favourable recovery (AOR = 0.989, 95 %CI 0.980-0.998) and living at home without care. CONCLUSION: In OHCA with an initially shockable rhythm, increasing CPR duration is associated with poorer long-term functional recovery and quality-of-life.
Abstract © the authors or publisher, via PubMed. Reuse and removal
Tags
Mortality & survival · Quality of life & function · Time intervals
Related articles
- Association between cardiopulmonary resuscitation duration and survival after out-of-hospital cardiac arrest according: a first nationwide study in France. (Intern Emerg Med, 2024)
- Impact of time-to-compression on out-of-hospital cardiac arrest survival outcomes: A national registry study. (Resuscitation, 2023)
- Identifying individuals satisfying the termination of resuscitation rule but having potential to achieve favourable neurological outcome following out-of-hospital cardiac arrest. (Resuscitation, 2023)
- Cardiopulmonary resuscitation duration and favorable neurological outcome after out-of-hospital cardiac arrest: a nationwide multicenter observational study in Japan (the JAAM-OHCA registry). (Crit Care, 2022)
- Time point for transport initiation in out-of-hospital cardiac arrest cases with ongoing cardiopulmonary resuscitation: a nationwide cohort study in Japan. (Acute Med Surg, 2022)
- Refractory out-of-hospital cardiac arrest with ongoing cardiopulmonary resuscitation at hospital arrival - survival and neurological outcome without extracorporeal cardiopulmonary resuscitation. (Crit Care, 2018)