Clinical Practice Guideline: The Outpatient Management of Fever in Children and Adolescents.
Deutsches Arzteblatt international · 2026-02-24 · Guideline / consensus
Abstract
BACKGROUND: Fever is one of the more common symptoms in children and adolescents, accounting for 20%-40% of all pediatric office visits and ca. 30% of all pediatric contacts with the emergency medical services. The present clinical practice guideline concerns the management of fever of acute onset in otherwise healthy children and adolescents in the outpatient setting. METHODS: A systematic literature search was conducted, with evaluation according to SIGN and GRADE. RESULTS: For neonates and infants under the age of 3 months, the body temperature should be measured rectally with a digital thermometer. From the age of 1 year onward, it can be measured with an infrared tympanic thermometer (sensitivity 77%, specificity 98%). For infants under the age of 3 months, temperatures above 40°C are associated with an elevated risk of severe bacterial infection (OR 6.3, 95% confidence interval [4.44; 8.95]); in older children, the height of the fever has little prognostic significance (p = 0.11). The decision whether to lower the fever by medical means should be based exclusively on the degree of suffering and impairment of the child. Antipyretic agents should not be given routinely. Parents and other carers should be educated about fever as a normal defense reaction of the body and should be made acquainted with the warning signs (impaired consciousness, cutaneous hemorrhage, dehydration, capillary refill time longer than 3 seconds). Children whose degree of suffering and impairment from fever calls for treatment can be given acetaminophen (10 to 15 mg/kg BW in each individual dose, no more than 4 times per day) or ibuprofen (10 mg/kg BW in each individual dose, no more than 3 times per day). CONCLUSION: This evidence-based clinical practice guideline establishes a differentiated, symptom-oriented approach to the outpatient management of fever and emphasizes the education of parents and other carers so that the unnecessary administration of antipyretic drugs can be avoided.
Tags
Analgesics · Children · Ibuprofen · NSAIDs · Paracetamol