Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests.
Emergency Medicine Clinics of North America · 2026-03-25 · Other / unclear
Abstract
Epinephrine use in cardiac arrest (CA) is associated with a greater likelihood of return of spontaneous circulation (ROSC) but this early potential benefit does not seem to translate to survival with good neurologic outcomes. Similarly, high-dose epinephrine may yield a small increase in ROSC but does not improve rates of hospital discharge, long-term survival, or improved neurologic outcomes compared to standard-dosed epinephrine. Higher cumulative doses of epinephrine (>3 mg) during CA has been consistently associated with poor neurologic outcomes following ROSC.
Abstract © the authors or publisher, via PubMed. Reuse and removal
Tags
Adrenaline · Cardiovascular drugs · Mortality & survival · Quality of life & function · Vasopressors
Related articles
- Comparative Efficacy and Safety of Intravenous Vasopressors in Pre-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis. (J Emerg Med, 2025)
- Standard dose epinephrine versus placebo in out of hospital cardiac arrest: A systematic review and meta-analysis. (Am J Emerg Med, 2019)
- Vasopressin or epinephrine for out-of-hospital cardiac arrest. (Ann Emerg Med, 2006)
- Vasopressors during adult cardiac arrest: A systematic review and meta-analysis. (Resuscitation, 2019)
- Vasopressors During Cardiopulmonary Resuscitation. A Network Meta-Analysis of Randomized Trials. (Crit Care Med, 2018)
- Vasopressin for cardiac arrest: meta-analysis of randomized controlled trials. (Resuscitation, 2012)