Prehospital Vital Signs, Including SpO2, Are Significantly Associated With Mortality and Mechanical Circulatory Support Requirement in Acute Myocardial Infarction Patients.
Circulation journal · 2025-09-30 · Registry study
Abstract
BACKGROUND: Early risk stratification for acute myocardial infarction (AMI) using prehospital vital signs, including percutaneous oxygen before oxygen supply (pre-SpO2), remains underexplored. METHODS AND RESULTS: We analyzed 3,006 AMI patients from the Mie ACS Registry. Patients were stratified by the prehospital Simple Risk Index (pre-SRI = [heart rate × (age / 10)2] / systolic blood pressure) and pre-SpO2levels. The primary outcome was 30-day death. Combined assessment of pre-SRI and pre-SpO2was superior to individual parameters for predicting 30-day death. In the multivariate analysis, combined assessment (SRI ≥34 and SpO2≤94%) was the strongest independent predictors of 30-day death (hazard ratio 3.98, P<0.001). CONCLUSIONS: Prehospital vital signs including pre-SpO2enable early high-risk identification, improving clinical decision-making for hospital selection.